Diffusion Models

The accelerating crisis of antimicrobial resistance (AMR) demands new computational methods to stay ahead of evolving pathogens. ApexOracle is a unified ML platform designed to both predict the activity of candidate compounds against specific bacterial strains and generate novel molecules de novo, proactively targeting future superbugs. Motivation and Scope Global Impact: AMR contributes to nearly 5 million deaths annually. Traditional Challenges: Standard drug discovery pipelines are slow, resource-intensive, and reactive. ApexOracle Goal: Integrate genomic context and molecular design into one end-to-end framework. ApexOracle Architecture Layman’s Explanation: Imagine you have three sets of clues: the code of the bacteria (its genome), a simple description of its behaviors (like a basic fact sheet), and the building blocks of a potential drug (a molecular recipe). ApexOracle acts like a super-smart detective that reads all three clues at once. It combines them, figures out which molecules might work best, and even drafts entirely new molecular recipes that could stop the bacteria in its tracks. ...

Associative memory is the ability to store patterns and retrieve them when presented with partial or noisy inputs. Inspired by how the human brain recalls memories, associative memory models are recurrent neural networks that converge to stored patterns over time. The tutorial ‘Modern Methods in Associative Memory’ by Krotov et al. offers an accessible overview for newcomers and a rigorous mathematical treatment for experts, bridging classical ideas with cutting-edge developments in deep learning. ...